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J Pediatr. 2008 Mar;152(3):416-21. doi: 10.1016/j.jpeds.2007.07.041. Epub 2007 Oct 22.

National surveillance of emergency department visits for outpatient adverse drug events in children and adolescents.

Author information

1
Epidemic Intelligence Service, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Erratum in

  • J Pediatr. 2008 Jun;152(6):893.

Abstract

OBJECTIVE:

To describe the national scope and magnitude of outpatient adverse drug events (ADEs) that lead to emergency department (ED) visits in children and adolescents.

STUDY DESIGN:

To conduct an active surveillance of patients 18 years of age or younger who came to EDs with ADEs from Jan 1, 2004, to Dec 31, 2005, through a nationally representative, stratified probability sample of 63 US hospitals with EDs. The main outcome measures were national estimates of the number, type, patient demographics, and clinical characteristics of ADEs.

RESULTS:

Annually, an estimated 158,520 patients </=18 years old (95% CI, 117,745-199,295; 2 per 1000 persons) were treated in EDs for ADEs. Almost half (49.4%) of these visits occurred in patients between 1 and 4 years of age. Unintentional overdoses were the most common type of ADE (44.9%), followed by allergic reactions (35%), and adverse effects (12.6%). Antimicrobial agents, analgesic medications, and respiratory medications accounted for almost half of ADEs (25.2%, 13.7%, and 10.6%, respectively). Fewer than 1 in 10 patients (9.5%) required hospitalization or extended observation.

CONCLUSIONS:

Interventions targeting unintentional overdoses of medications commonly given to preschool-aged children would likely have the highest impact in reducing ED visits from outpatient ADEs.

PMID:
18280852
DOI:
10.1016/j.jpeds.2007.07.041
[Indexed for MEDLINE]

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