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J Pediatr. 2008 Mar;152(3):343-8. doi: 10.1016/j.jpeds.2007.07.014. Epub 2007 Oct 22.

Ambulatory blood pressure and increased left ventricular mass in children at risk for hypertension.

Author information

1
Department of Pediatrics, University of Tennessee Health Science Center, General Clinical Research Center, Children's Foundation Research Center at Le Bonheur Children's Medical Center, Memphis, Tennessee, USA.

Abstract

OBJECTIVE:

To relate ambulatory blood pressure (ABP) to cardiac target organ measurement in children at risk for primary hypertension (HTN).

STUDY DESIGN:

Left ventricular mass index (LVMI) and ABP were measured concomitantly in children (6 to 18 years) at risk for hypertension using a cross-sectional study design.

RESULTS:

LVMI showed a significant positive correlation with 24-hour systolic blood pressure (SBP) load, SBP index (SBPI), and standard deviation score (SDS). When subjects were stratified by LVMI percentile, there were significant differences in SBP load, 24-hour SBPI, and 24-hour SSDS. The odds ratio (OR) of having elevated LVMI increased by 54% for each incremental increase of SDS in 24-hour SSDS after controlling for race and BMI (OR = 1.54, unit = 1 SDS, CI = 1.1, 2.15, P = .011) and increased by 88% for each increase of 0.1 in BPI (OR = 1.88, CI = 1.03, 3.45, P = .04). Subjects with stage 3 HTN had significantly greater mean LVMI compared with normal subjects (P = .002 by ANOVA; LMVI, 31.6 +/- 7.9 versus 39.5 +/- 10.4).

CONCLUSIONS:

As systolic ABP variables increase, there is greater likelihood for increased LVMI. Staging based on ABPM allows assessment of cardiovascular risk in children with primary hypertension.

PMID:
18280838
PMCID:
PMC2763428
DOI:
10.1016/j.jpeds.2007.07.014
[Indexed for MEDLINE]
Free PMC Article

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