Format

Send to

Choose Destination
See comment in PubMed Commons below
Brain Dev. 2008 Aug;30(7):454-60. doi: 10.1016/j.braindev.2007.12.007. Epub 2008 Feb 15.

Use of clonidine in children with autism spectrum disorders.

Author information

1
Department of Neuroscience and Pediatrics, UMDNJ - New Jersey Medical School, 90 Bergen Street, Doctor's Office Center 8100, Newark, NJ 07103, USA. mingxu@umdnj.edu

Abstract

Children with autism spectrum disorders (ASD) often exhibit sleep and behavioral disorders. Treatment of sleep disorders can be difficult in these children. Clonidine, an alpha2-adrenergic receptor agonist, has been shown to be effective in reducing impulsivity, inattention, and hyperactivity, as well as in serving as a sedative for medial procedures. An open labeled retrospective study of clonidine in treatment of insomnia, and/or hyperactivity, inattention, mood disorder, and aggressive behaviors was conducted using parent reports of sleep initiation and maintenance, as well as behaviors prior and during clonidine treatment. Clonidine was effective in reducing sleep initiation latency and night awakening, to a less degree in improving attention deficits hyperactivity, mood instability and aggressiveness in this cohort of 19 children with ASD. The side effects were largely tolerable. Further evaluation with placebo-controlled double-blind clinical trial of clonidine use in ASD will provide more insight into the clinical efficacy and safety of the medicine in ASD.

PMID:
18280681
DOI:
10.1016/j.braindev.2007.12.007
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center