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Breast Cancer Res. 2008;10(1):302. doi: 10.1186/bcr1853. Epub 2008 Feb 8.

Re-evaluating early breast neoplasia.

Author information

1
Department of Pathology, Harvard Medical School, Molecular Pathology Research Unit, Massachusetts General Hospital, Boston, Massachusetts 02129, USA.

Abstract

Historically, histomorphological and epidemiological data suggested that atypical ductal hyperplasia and ductal carcinoma in situ are the earliest recognizable neoplastic stages of breast cancer progression. Over the past several years, detailed high-throughput molecular genetic, gene expression and epigenetic analyses have enhanced our understanding of these early neoplastic lesions and have re-shaped our view of human breast cancer progression to include multiple distinct pathways of evolution.

PMID:
18279539
PMCID:
PMC2374963
DOI:
10.1186/bcr1853
[Indexed for MEDLINE]
Free PMC Article

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