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Clin Genet. 2008 Apr;73(4):367-72. doi: 10.1111/j.1399-0004.2008.00966.x. Epub 2008 Feb 13.

A locus for autosomal dominant progressive non-syndromic hearing loss, DFNA27, is on chromosome 4q12-13.1.

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National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA.


We ascertained a large North American family, LMG2, segregating progressive, non-syndromic, sensorineural hearing loss. A genome-wide scan identified significant evidence for linkage (maximum logarithm of the odds (LOD) score = 4.67 at theta = 0 for D4S398) to markers in a 5.7-cM interval on chromosome 4q12-13.1. The DFNA27 interval spans 8.85 Mb and includes at least 61 predicted and 8 known genes. We sequenced eight genes and excluded them as candidates for the DFNA27 gene.

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