Format

Send to

Choose Destination
See comment in PubMed Commons below
ACS Chem Biol. 2008 Feb 15;3(2):89-91. doi: 10.1021/cb800024g.

How the "melting" and "freezing" of protein molecules may be used in cell signaling.

Author information

1
Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK. db10009@cam.ac.uk

Abstract

The motile response of Escherichia coli bacteria to attractants and repellents is one of the best-understood examples of a signal transduction pathway. A number of recent studies suggest that the receptors in this system undergo major changes in both their degree of structural order and their state of aggregation in the membrane. We discuss the thermodynamic basis for this effect and argue that the "freezing" or "melting" of protein structure may be the language of signaling.

PMID:
18278848
DOI:
10.1021/cb800024g
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Support Center