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Nat Med. 2008 Mar;14(3):255-7. doi: 10.1038/nm1730. Epub 2008 Feb 17.

Perivascular nitric oxide gradients normalize tumor vasculature.

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1
Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, Massachusetts 02114, USA.

Abstract

Normalization of tumor vasculature is an emerging strategy to improve cytotoxic therapies. Here we show that eliminating nitric oxide (NO) production from tumor cells via neuronal NO synthase silencing or inhibition establishes perivascular gradients of NO in human glioma xenografts in mice and normalizes the tumor vasculature, resulting in improved tumor oxygenation and response to radiation treatment. Creation of perivascular NO gradients may be an effective strategy for normalizing abnormal vasculature.

PMID:
18278052
DOI:
10.1038/nm1730
[Indexed for MEDLINE]
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