Format

Send to

Choose Destination
Nat Biotechnol. 2008 Mar;26(3):313-5. doi: 10.1038/nbt1383. Epub 2008 Feb 17.

Marked differences in differentiation propensity among human embryonic stem cell lines.

Author information

1
Harvard Stem Cell Institute, 42 Church Street, Cambridge, Massachusetts 02138, USA.

Abstract

The differentiation potential of 17 human embryonic stem (hES) cell lines was compared. Some lines exhibit a marked propensity to differentiate into specific lineages, often with >100-fold differences in lineage-specific gene expression. For example, HUES 8 is best for pancreatic differentiation and HUES 3 for cardiomyocyte generation. These non-trivial differences in developmental potential among hES cell lines point to the importance of screening and deriving lines for lineage-specific differentiation.

PMID:
18278034
DOI:
10.1038/nbt1383
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center