Griseusin D, a new pyranonaphthoquinone derivative from a alkaphilic Nocardiopsis sp

J Antibiot (Tokyo). 2007 Dec;60(12):757-61. doi: 10.1038/ja.2007.100.

Abstract

A new pyranonaphthoquinone antibiotic, griseusin D (1) was isolated from the cultural fluid of the alkaphilic Nocardiopsis sp. The structure was determined as 5'-one-4-hydroxy-12-methoxygriseusin by spectroscopic methods, comparison with reported data and single-crystal X-ray analysis. 1 displayed strong cytotoxicity against human leukemia cells (HL60) and modest cytotoxicity against human lung adenocarcinoma cell lines (AGZY) with IC(50) values of 0.23 and 19.6 microg/ml, respectively. It also exhibited weak antifungal activity against Alternaria alternate with MIC of 140 microg/ml.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actinomycetales / metabolism*
  • Alternaria / drug effects
  • Antibiotics, Antineoplastic / chemistry*
  • Antibiotics, Antineoplastic / isolation & purification
  • Antibiotics, Antineoplastic / pharmacology*
  • Antifungal Agents / chemistry*
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology*
  • Cell Line, Tumor
  • Crystallography, X-Ray
  • Culture Media / chemistry
  • Humans
  • Inhibitory Concentration 50
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Naphthoquinones / chemistry
  • Naphthoquinones / isolation & purification
  • Naphthoquinones / pharmacology
  • Spectrum Analysis

Substances

  • Antibiotics, Antineoplastic
  • Antifungal Agents
  • Culture Media
  • Naphthoquinones
  • griseusin