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J Antibiot (Tokyo). 2007 Dec;60(12):752-6. doi: 10.1038/ja.2007.99.

Isolation of 8'-phosphate ester derivatives of amicoumacins: structure-activity relationship of hydroxy amino acid moiety.

Author information

1
Reseach Institute of Pharmaceutical Sciences, Musashino University, Shinmachi, Nishitokyo, Tokyo, Japan.

Erratum in

  • J Antibiot (Tokyo). 2008 Jan;61(1):C-1.

Abstract

Two new compounds, 8'-phospho derivatives of amicoumacins A and B, were isolated from the culture broth of a strain of Bacillus pumilus together with amicoumacins A and B. Their structures were elucidated on the basis of spectroscopic methods and alkaline phosphatase treatments. Comparison of the antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) of these compounds suggested that C-8' hydroxyl and C-12' amide group of amicoumacin A played a critical role for anti-MRSA activity.

PMID:
18277000
DOI:
10.1038/ja.2007.99
[Indexed for MEDLINE]

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