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Clin Radiol. 2008 Mar;63(3):241-51. doi: 10.1016/j.crad.2007.11.008. Epub 2008 Jan 14.

The role of hybrid SPECT-CT in oncology: current and emerging clinical applications.

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Department of Clinical Radiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.


Single photon emission computed tomography - computed tomography (SPECT-CT) is an emerging dual-modality imaging technique with many established and potential clinical applications in the field of oncology. To date, there has been a considerable emphasis on the benefits of integrated positron emission tomography - computed tomography (PET-CT) in oncology, but relatively little focus on the clinical utility of SPECT-CT. As with PET-CT, accurate co-registration of anatomical and functional data from a combined SPECT-CT camera often provides complementary diagnostic information. Both sensitivity (superior disease localization) and specificity (exclusion of false-positives due to physiological tracer uptake) are improved, and the functional significance of indeterminate lesions detected on cross-sectional imaging can be defined. This article will review the scope of hybrid SPECT-CT in oncology and illustrate both current and emerging clinical applications.

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