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AIDS Res Hum Retroviruses. 2008 Jan;24(1):86-91. doi: 10.1089/aid.2007.0190.

HIV type 2 intergroup recombinant identified in Cameroon.

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1
Abbott Diagnostics, Abbott Park, Illinois 60064, USA.

Abstract

A unique HIV-2 intergroup recombinant strain was identified in Cameroon. The virus, CM-03-510-03, was amplified from blood collected from a 47-year-old female patient in Douala, Cameroon in 2003 who was seroreactive for HIV-2. A near full-length genome 9089 nucleotides in length was amplified from proviral DNA. The genome for CM-03-510-03 is composed of segments of HIV-2 groups A and B with four recombination break-points and has open reading frames for all the structural and regulatory genes. A comparison of CM-03-510-03 to the only previously reported HIV-2 intergroup recombinant shows that the two strains share one recombination breakpoint but are otherwise distinct from each other. Similar to HIV-1, HIV-2 intergroup recombination is an indication that coinfection with more than one strain has occurred in individuals and is a mechanism that increases strain genetic diversity.

PMID:
18275352
DOI:
10.1089/aid.2007.0190
[Indexed for MEDLINE]
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