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J Infect Dis. 2008 Feb 15;197(4):618-21. doi: 10.1086/526500.

Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis.

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School of Health Sciences, University of Minho, Braga, Portugal.


Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P =.003). Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P =. 043). No particular polymorphism was associated with severe asthma with fungal sensitization. These findings reinforce the importance of innate immunity in the pathogenesis of different forms of aspergillosis.

[Indexed for MEDLINE]

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