We investigated which frame of reference is evoked during implicit motor sequence learning. Participants completed a typical serial reaction time task. In the first experiment, we isolated egocentric and allocentric frames of reference and found that learning was solely in an egocentric reference frame. In a second experiment, we isolated hand-centered space from other egocentric frames of reference. We found that for a one-handed sequencing task, the sequence was coded in an egocentric reference frame but not a hand-centered reference frame. Our results are restricted to implicit learning of novel sequences in the early stages of learning. These findings are consistent with claims that the neural mechanisms involved in motor skill learning operate in egocentric coordinates.