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Kidney Int. 2008 Mar;73(5):524-6. doi: 10.1038/sj.ki.5002741.

Nephrin AKTs on actin: The slit diaphragm-actin cytoskeleton signaling network expands.

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1
Department of Medicine, Renal Division, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. jschlondorff@partners.org

Abstract

Regulation and maintenance of the actin cytoskeleton of podocytes has emerged as a critical process for preserving glomerular permselectivity. Signaling through nephrin, a crucial component of the slit diaphragm, can lead to rearrangement of the actin cytoskeleton. Zhu et al. identify phosphoinositide 3-kinase-dependent activation of Akt and Rac as mediators of nephrin-induced actin reorganization, expanding the signaling network linking two of the podocyte's unique structures, its actin cytoskeleton and the slit diaphragm.

PMID:
18274541
DOI:
10.1038/sj.ki.5002741
[Indexed for MEDLINE]
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