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Scand Cardiovasc J. 2008 Feb;42(1):3-8. doi: 10.1080/14017430701798838.

Curative ablation for atrial fibrillation: a systematic review.

Author information

1
Faculty Division Ullevål, Oslo University and Department of Cardiology, Ullevål University Hospital, Oslo, Norway. knut.gjesdal@medisin.uio.no

Abstract

OBJECTIVE:

To perform a systematic review of randomized controlled trials (RCTs) on catheter ablation for atrial fibrillation (AF).

BACKGROUND:

Radiofrequency catheter (RF)-ablation around pulmonary vein ostia and in left atrium may reduce or prevent recurrence of AF, as documented in observational studies and registry reports; however, few RCTs are available.

METHODS:

Using relevant search phrases, Cochrane Library, MEDLINE and EMBASE were searched for RCTs, last time in May 2007. Titles and abstracts were screened. When entry criteria were fulfilled, full-text papers were read and graded according to quality and relevance.

RESULTS:

One thousand and ninety four abstracts were evaluated, and five RCTs included (578 randomized patients). The studies had moderate quality and relevance, but the results were consistent: ablation is better than drug treatment in preventing AF recurrence; the relative risk (95% CI)) one year after ablation ranged from 0.20 (0.08-0.51) to 0.62 (0.39-0.99).

CONCLUSIONS:

Results from observational and registry studies are confirmed: RF-ablation reduces recurrence rate of AF, and can be done with few serious complications. Limitations are few patients>70 years, and only one year follow-up.

PMID:
18273730
DOI:
10.1080/14017430701798838
[Indexed for MEDLINE]
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