Format

Send to

Choose Destination
EMBO J. 2008 Mar 19;27(6):910-20. doi: 10.1038/emboj.2008.22. Epub 2008 Feb 14.

ShcA signalling is essential for tumour progression in mouse models of human breast cancer.

Author information

1
Department of Medicine, McGill University, McGill University Health Center, Montreal, Quebec, Canada.

Abstract

To explore the in vivo significance of ShcA during mammary tumorigenesis, we used mice expressing several phosphotyrosine-deficient ShcA alleles under the control of their endogenous promoter. We show that all three ShcA tyrosine phosphorylation sites are involved in the early stages of mammary tumour progression, including loss of the myoepithelial cell layer surrounding hyperplasias and during progression to carcinoma. We have determined that signals emanating from Y313 are important for tumour cell survival, whereas Y239/240 transduce signals promoting tumour vascularization. We further demonstrate that loss of ShcA expression in mammary epithelial cells abrogates tumour development. This study is the first to directly demonstrate that signalling downstream from the ShcA adaptor protein is critical for breast cancer development.

PMID:
18273058
PMCID:
PMC2274931
DOI:
10.1038/emboj.2008.22
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center