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Dement Geriatr Cogn Disord. 2008;25(3):256-65. doi: 10.1159/000115975. Epub 2008 Feb 13.

Cerebrospinal fluid neurochemical phenotypes in vascular dementias: original data and mini-review.

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1
Klinik fur Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universitat Duisburg-Essen, Essen, Germany. mbibl@gwdg.de

Abstract

BACKGROUND/AIMS:

The study evaluated the patterns of cerebrospinal fluid (CSF), amyloid-beta (Abeta) peptides, total tau and phospho-tau among Alzheimer's disease (AD) and vascular dementias (VAD).

METHODS:

Abeta-SDS-PAGE immunoblot and commercially available ELISAs were applied to the CSF analysis of 52 patients with probable (n = 21) and possible (n = 16) VAD, AD with cerebrovascular disease (n = 15), 30 patients with probable AD and 30 nondemented disease controls.

RESULTS:

AD and AD with cerebrovascular disease displayed a similar neurochemical phenotype in contrast to nondemented disease controls and probable VAD with regard to tau, p-tau, Abeta1-40(ox) and Abeta1-42%. Possible VAD displayed AD-like changes only for Abeta1-40(ox) and Abeta1-42%.

CONCLUSION:

CSF neurochemical phenotypes sufficiently discriminate probable AD and VAD from each other, but their diagnostic value is limited in case of no clear-cut clinical appearance, such as possible VAD. Conversely, CSF Abeta peptides and p-tau levels may help estimate the involvement of AD-like pathophysiological pathways in VAD subgroups.

PMID:
18270488
DOI:
10.1159/000115975
[Indexed for MEDLINE]
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