Format

Send to

Choose Destination
See comment in PubMed Commons below
Cancer Epidemiol Biomarkers Prev. 2008 Feb;17(2):343-51. doi: 10.1158/1055-9965.EPI-07-0428.

Plasma tea polyphenols and gastric cancer risk: a case-control study nested in a large population-based prospective study in Japan.

Author information

1
Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. ssasazuk@gan2.res.ncc.go.jp

Abstract

Abundant in vitro and animal studies have shown a protective effect of green tea against various types of cancer, but the evidence from epidemiologic studies is inconclusive. In this nested case-control study, we used plasma biomarkers to directly investigate the effect of tea polyphenols on the risk of gastric cancer. Subjects were followed up from 1990 to 2004. Among 36,745 subjects who answered the baseline questionnaire and provided blood samples, 494 gastric cancer cases matched to 494 controls were used in the analysis. The validated method used high-performance liquid chromatography to analyze baseline plasma samples. For men, a high plasma level of (-)-epigallocatechin was associated with an increased risk of gastric cancer. For women, a high plasma level of (-)-epicatechin-3-gallate (ECG) was associated with a decreased risk of gastric cancer; the adjusted odds ratios (95% confidence intervals) for ECG levels 0.32 to 9.2 and 9.3+ ng/mL were 1.03 (0.41-2.59) and 0.25 (0.08-0.73), respectively, compared with those whose ECG level was under the detection limit (P for trend = 0.02). Cigarette smoking was suggested to play a role as an effect modifier, which explains in part the different patterns observed by gender.

PMID:
18268118
DOI:
10.1158/1055-9965.EPI-07-0428
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center