Format

Send to

Choose Destination
Antimicrob Agents Chemother. 2008 Apr;52(4):1493-5. doi: 10.1128/AAC.01367-07. Epub 2008 Feb 11.

Malaria treatment with atovaquone-proguanil in malaria-immune adults: implications for malaria intervention trials and for pre-exposure prophylaxis of malaria.

Author information

1
Walter Reed Project, United States Army Medical Research Unit, Kisumu, Kenya. mpolhemus@wrp-ksm.org

Abstract

Eighty adults in areas of Kenya where malaria is holoendemic received presumptive treatment with atovaquone-proguanil and were followed closely. The time to the first Plasmodium falciparum parasitemia was 32 days. This prolonged prophylaxis period has implications for study design when used in malaria intervention trials and cautiously suggests clinical investigation of potential preexposure prophylaxis of malaria.

PMID:
18268090
PMCID:
PMC2292568
DOI:
10.1128/AAC.01367-07
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center