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Parkinsonism Relat Disord. 2007;13 Suppl 3:S306-8. doi: 10.1016/S1353-8020(08)70021-X.

Mechanisms of neurodegeneration in idiopathic Parkinson's disease.

Author information

1
Department of Neurodegeneration & Restorative Research, Center for Neurological Medicine, University Medical Center Göttingen, Germany. jschulz4@gwdg.de

Abstract

The discovery of mutations in hereditary forms of Parkinson's disease has implicated aggregation of a-synuclein, dysfunction of protein turnover and mitochondrial dysfunction as important mediators in the pathogenesis of Parkinson's disease. Subsequent studies have shown that these factors also represent hallmarks of idiopathic Parkinson's disease. Cell death mechanisms include excitotoxicity, calcium overload, apoptosis and autophagia. Here, I will briefly review the molecular mechanisms of neurodegeneration in Parkinson's disease and point out potential treatment options.

PMID:
18267255
DOI:
10.1016/S1353-8020(08)70021-X
[Indexed for MEDLINE]

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