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Dev Cell. 2008 Feb;14(2):156-8. doi: 10.1016/j.devcel.2008.01.010.

Running rings around chromosomes to trim axons and target dendrites.

Author information

1
Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1100 South Grand Boulevard, Saint Louis, MO 63104, USA. dorsettd@slu.edu

Abstract

The cohesin protein complex holds sister chromatids together to ensure proper chromosome segregation at mitosis in dividing cells. New experiments by two laboratories (reviewed in this issue of Developmental Cell) using different techniques reveal that cohesin also plays critical roles in morphogenesis of nondividing neurons. Other recent studies argue that these roles involve regulation of gene transcription.

PMID:
18267084
DOI:
10.1016/j.devcel.2008.01.010
[Indexed for MEDLINE]
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