Aspergillus "fungus ball" of the bladder after hematopoietic transplantation in a pediatric patient: successful treatment with intravesical voriconazole and surgery

Pediatr Transplant. 2008 Mar;12(2):242-5. doi: 10.1111/j.1399-3046.2007.00871.x. Epub 2008 Feb 6.

Abstract

Aspergillosis is an important cause of mortality in allogeneic HSCT. A "fungus ball" formation of Aspergillus in the bladder has seldom been reported. We report a child that underwent HSCT and developed possible disseminated aspergillosis with an intravesical "fungus ball," diagnosed by genitourinary MRI and PCR of the mass that was removed from the bladder. It is important to consider this complication in a patient with HC after HSCT. The treatment included a combination of systemic antifungal therapy along with intravesical voriconazole and surgical removal.

Publication types

  • Case Reports

MeSH terms

  • Administration, Intravesical
  • Adolescent
  • Anemia, Sickle Cell / therapy
  • Antifungal Agents / therapeutic use*
  • Aspergillosis / etiology
  • Aspergillosis / surgery
  • Aspergillosis / therapy*
  • Cystitis / etiology
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Male
  • Pyrimidines / therapeutic use*
  • Triazoles / therapeutic use*
  • Urinary Bladder Diseases / etiology
  • Urinary Bladder Diseases / surgery
  • Urinary Bladder Diseases / therapy*
  • Voriconazole

Substances

  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Voriconazole