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Int J Clin Pract. 2008 Apr;62(4):642-8. doi: 10.1111/j.1742-1241.2008.01705.x. Epub 2008 Feb 7.

Prediabetes: a must to recognise disease state.

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1
Department of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Canada.

Abstract

Prediabetes mellitus (PDM) is defined as a state of abnormal glucose homeostasis in which deficiency or resistance to insulin is the hallmark. PDM precedes the development of overt type 2 DM. It is associated with increased mortality and morbidity and thus fits well with the criteria of a disease condition. Framing PDM as a disease and not a risk or a 'pre' stage for diabetes is needed to facilitate early management.

AIM:

This review aims therefore to increase awareness of PDM as a disease state.

METHODS:

To do so, we shall preview guidelines for its diagnosis. Its prevalence and hazards will be then discussed. Finally, we shall elaborate on the current treatment guidelines.

RESULT:

Enough evidence support the notion that PDM is a curable disease state.

CONCLUSIONS:

The current recommendations for the treatment of PDM should be adhered. In addition, there is a room for the use of other pharmacological agents.

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