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J Infect Dis. 2008 Mar 1;197(5):733-6. doi: 10.1086/526501.

High Mycoplasma genitalium organism burden is associated with shedding of HIV-1 DNA from the cervix.

Author information

1
Department of Epidemiology, University of Washington, Seattle, WA 98104-2499, USA. lmanhart@u-washington.edu

Abstract

We assessed the relationship between infection with Mycoplasma genitalium, an emerging sexually transmitted pathogen, and cervical shedding of human immunodeficiency virus (HIV)-1 DNA among 303 HIV-1-positive Kenyan women. HIV-1 shedding was detected by qualitative polymerase chain reaction (PCR) in 154 women (51%); M. genitalium was detected by qualitative PCR in 52 (17%), and organism burden was determined by quantitative PCR. Women with high M. genitalium organism burdens (more than the median of 3195 genomes/mL) were 3-fold more likely to shed HIV-1 DNA than were M. genitalium-negative women (adjusted OR, 2.9 [95% confidence interval, 1.1-7.6]), yet this did not appear to be mediated by traditional measures of cervical inflammation (elevated polymorphonuclear leukocyte count).

PMID:
18266605
PMCID:
PMC4090222
DOI:
10.1086/526501
[Indexed for MEDLINE]
Free PMC Article

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