Send to

Choose Destination
J Infect Dis. 2008 Mar 1;197(5):676-80. doi: 10.1086/527488.

Vitamin D receptor polymorphisms and the risk of acute lower respiratory tract infection in early childhood.

Author information

Department of Pediatrics,University of Alberta, Edmonton, Canada.


To investigate associations of 2 vitamin D receptor (VDR) gene polymorphisms and acute lower respiratory tract infection (ALRI), we compared 56 young children hospitalized with ALRI and 64 children without a history of ALRI. The FokI ff genotype was associated with an adjusted relative odds of ALRI that was approximately 7 times that of FokI FF. A weaker association with the TaqI polymorphism was also found. These data provide preliminary evidence of associations of VDR polymorphisms with the risk of ALRI (predominantly viral bronchiolitis) in young children, consistent with a potential role of vitamin D in the immune response to respiratory tract infection.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center