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Int J Hematol. 2008 Mar;87(2):172-175. doi: 10.1007/s12185-008-0027-1. Epub 2008 Feb 13.

hSNF5 /INI1 mutation analysis in acute myeloid leukemia.

Author information

1
Division of Hematology-Oncology, Department of Internal Medicine, Buddhist Dalin TzuChi General Hospital, No. 2, Ming-Shen Road, Chiayi County, Taiwan. hepatoma@ms3.hinet.net.
2
Department of Chemical Engineering, National Chung Cheng University, Chiayi, Taiwan.
3
Division of Hematology-Oncology, Department of Internal Medicine, Buddhist Dalin TzuChi General Hospital, No. 2, Ming-Shen Road, Chiayi County, Taiwan.

Abstract

Previous studies indicated that region 11.2 of the long arm of chromosome 22 (22q11.2) might be a locus encoding a tumor suppressor gene, since its deletion is a recurrent genetic characteristic of aggressive pediatric cancer. This region is found in the human immunodeficiency virus integrase interactor 1 (hSNF5/INI1) gene. To investigate whether the hSNF5/INI1 gene is involved in leukemogenesis, mutation analysis of the hSNF5/INI1 gene was performed in the present study using 5 hematopoietic cell lines, acute myeloid leukemia (AML) specimen and normal control. We found two single nucleotide polymorphisms at the hSNF5/INI1 gene in exon 4 and exon 9. The results of this study suggest that the hSNF5/INI1 gene does not play an important role in the leukemogenesis of AML.

PMID:
18266055
DOI:
10.1007/s12185-008-0027-1
[Indexed for MEDLINE]

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