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Immunol Today. 1991 Jan;12(1):35-41.

Phosphatidylinositol membrane anchors and T-cell activation.

Author information

1
Transplantation Biology Section, Clinical Research Centre, Harrow, Middlesex, UK.

Abstract

A number of lymphocyte proteins are attached to the cell membrane via glycophosphatidylinositol-anchoring domains. Antibodies specific for several of these proteins are potent mitogens for T cells. In this article, Peter Robinson reviews recent evidence for the involvement of these membrane anchors in cell signalling events and discusses their possible significance in providing antigen-independent costimulatory signals to lymphoid cells.

PMID:
1826601
DOI:
10.1016/0167-5699(91)90110-F
[Indexed for MEDLINE]

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