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Phys Med Biol. 2008 Feb 21;53(4):937-51. doi: 10.1088/0031-9155/53/4/008. Epub 2008 Jan 23.

Beveled fiber-optic probe couples a ball lens for improving depth-resolved fluorescence measurements of layered tissue: Monte Carlo simulations.

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1
Bioimaging Laboratory, Department of Bioengineering, Faculty of Engineering, National University of Singapore, Singapore.

Abstract

In this study, we evaluate the feasibility of designing a beveled fiber-optic probe coupled with a ball lens for improving depth-resolved fluorescence measurements of epithelial tissue using Monte Carlo (MC) simulations. The results show that by using the probe configuration with a beveled tip collection fiber and a flat tip excitation fiber associated with a ball lens, discrimination of fluorescence signals generated in different tissue depths is achievable. In comparison with a flat-tip collection fiber, the use of a large bevel angled collection fiber enables a better differentiation between the shallow and deep tissue layers by changing the excitation-collection fiber separations. This work suggests that the beveled fiber-optic probe coupled with a ball lens has the potential to facilitate depth-resolved fluorescence measurements of epithelial tissues.

PMID:
18263950
DOI:
10.1088/0031-9155/53/4/008
[Indexed for MEDLINE]
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