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Trends Cell Biol. 2008 Mar;18(3):98-104. doi: 10.1016/j.tcb.2008.01.001. Epub 2008 Feb 11.

A decade of surprises for tRNA nuclear-cytoplasmic dynamics.

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Department of Molecular Genetics, Ohio State University, 484 West 12th Avenue, Room Riffe 800, Columbus, OH 43210, USA.


The biosynthesis of tRNA was previously thought to occur solely in the nucleus, with tRNA functioning only in the cytoplasm of eukaryotic cells. However, recent publications have reported that pre-tRNA splicing can occur in the cytoplasm, that aminoacylation can occur in the nucleus and that tRNA can travel in a retrograde direction from the cytoplasm to the nucleus. Moreover, the subcellular distribution of tRNA seems to serve unanticipated functions in diverse processes, including response to nutrient availability, DNA repair and HIV replication.

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