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Prog Neuropsychopharmacol Biol Psychiatry. 2008 Apr 1;32(3):886-90. doi: 10.1016/j.pnpbp.2008.01.004. Epub 2008 Jan 11.

Effect of treatment on serum glial cell line-derived neurotrophic factor in depressed patients.

Author information

1
Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, No.87 DingJiaQiao Road, Nanjing, PR China, 210009. zhangxiaobim@163.com

Abstract

Post-mortem studies have demonstrated a decreased number of glia, reduced glial density, and a decreased glia/neuron ratio in different brain areas of patients diagnosed with a major depressive disorder (MDD). Researchers have therefore suggested that neurotrophic growth factor systems might be involved in the aetiology of MDD. This study aimed to test whether glial cell line-derived neurotrophic factor (GDNF), a member of the transforming growth factor beta family, in serum was associated with MDD. Serum concentrations were measured in MDD patients before treatment (n=76), after 8 weeks of antidepressant treatment (n=39), and in control subjects (n=50) using a sandwich ELISA method. Serum GDNF was significantly lower in MDD patients before treatment than in control subjects (P<0.001). From baseline to remission after 8 weeks of treatment, the increase in serum GDNF was statistically significant (P<0.001). The present study suggests that lower serum GDNF might be involved in the pathophysiology of MDD and antidepressant treatment increases the GDNF in MDD.

PMID:
18262703
DOI:
10.1016/j.pnpbp.2008.01.004
[Indexed for MEDLINE]

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