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Trends Mol Med. 2008 Mar;14(3):120-33. doi: 10.1016/j.molmed.2008.01.002. Epub 2008 Feb 11.

Airway epithelial control of Pseudomonas aeruginosa infection in cystic fibrosis.

Author information

1
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Defective expression or function of the cystic fibrosis transmembrane conductance regulator (CFTR) underlies the hypersusceptibility of cystic fibrosis (CF) patients to chronic airway infections, particularly with Pseudomonas aeruginosa. CFTR is involved in the specific recognition of P. aeruginosa, thereby contributing to effective innate immunity and proper hydration of the airway surface layer (ASL). In CF, the airway epithelium fails to initiate an appropriate innate immune response, allowing the microbe to bind to mucus plugs that are then not properly cleared because of the dehydrated ASL. Recent studies have identified numerous CFTR-dependent factors that are recruited to the epithelial plasma membrane in response to infection and that are needed for bacterial clearance, a process that is defective in CF patients hypersusceptible to infection with this organism.

PMID:
18262467
PMCID:
PMC3697050
DOI:
10.1016/j.molmed.2008.01.002
[Indexed for MEDLINE]
Free PMC Article

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