Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2008 Mar 1;18(5):1567-72. doi: 10.1016/j.bmcl.2008.01.081. Epub 2008 Jan 30.

Pyrogallol and its analogs can antagonize bacterial quorum sensing in Vibrio harveyi.

Author information

1
Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.

Abstract

Bacteria can coordinate community-wide behaviors through quorum sensing, that is, the secretion and sensing of autoinducer (AI) molecules. Bacterial quorum sensing is implicated in the regulation of pathologically relevant events such as biofilm formation, bacterial virulence, and drug resistance. Inhibitors of bacterial quorum sensing could therefore be useful therapeutics. Herein we report for the first time the discovery of several pyrogallol compounds as single digit micromolar inhibitors of bacterial quorum sensing in Vibrio harveyi.

PMID:
18262415
DOI:
10.1016/j.bmcl.2008.01.081
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center