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Biochem Biophys Res Commun. 2008 Apr 11;368(3):588-92. doi: 10.1016/j.bbrc.2008.01.131. Epub 2008 Feb 7.

Developmental and reproductive consequences of prolonged non-aging dauer in Caenorhabditis elegans.

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Department of Biochemistry, College of Life Science and Biotechnology and Yonsei Proteome Research Center, Yonsei University, 134 Shinchon-dong, Sudeamoon-ku, Seoul 120-749, Republic of Korea.


When Caenorhabditis elegans encounters harsh environmental conditions, it enters a non-aging diapause (dauer), an alternative larval stage capable of long-term survival. This replaces the stage of normal development critical for development of the reproductive organs. Here, we report that increased duration of diapause causes a delay in post-dauer development, and also causes severe defects in the reproductive development of males and hermaphrodites. Thus, the dauer state, while allowing for survival under adverse conditions, has important developmental and reproductive consequences. This effect is more pronounced in males, possibly accounting for the increased survival of C. elegans hermaphrodites in challenging environmental conditions.

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