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Cancer Invest. 2008 Mar;26(2):145-51. doi: 10.1080/07357900701577475.

TAE226 inhibits human neuroblastoma cell survival.

Author information

  • 1Department of Surgery, University of Florida, Gainesville, Florida 32610-0286, USA. beierea@surgery.ufl.edu

Abstract

PURPOSE:

Neuroblastoma is one of the most devastating pediatric solid tumors and is unresponsive to many interventions. TAE226 is a novel small molecule FAK inhibitor. We investigated the effects of TAE226 on neuroblastoma cells in vitro.

MATERIALS AND METHODS:

Human neuroblastoma cell lines were treated with varying concentrations of TAE226. Following treatment, cell viability, cell cycle, and apoptosis were evaluated.

RESULTS:

Treatment of human neuroblastoma cell lines with TAE226 resulted in a concentration dependent decrease in FAK phosphorylation, decrease in cellular viability, cell cycle arrest, and an increase in apoptosis.

CONCLUSIONS:

Targeting FAK provides potential therapeutic options for the treatment of neuroblastoma and deserves further investigation.

PMID:
18259944
DOI:
10.1080/07357900701577475
[PubMed - indexed for MEDLINE]
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