Format

Send to

Choose Destination
Breast Cancer Res Treat. 2009 Jan;113(1):137-44. doi: 10.1007/s10549-008-9912-9. Epub 2008 Feb 8.

Is chemotherapy necessary for premenopausal women with lower-risk node-positive, endocrine responsive breast cancer? 10-year update of International Breast Cancer Study Group Trial 11-93.

Collaborators (308)

Goldhirsch A, Coates AS, Thürlimann B, Castiglione-Gertsch M, Coates AS, Gelber RD, Goldhirsch A, Green M, Hiltbrunner A, Holmberg SB, Hossfeld DK, Láng I, Stahel R, de Stoppani M, Veronesi A, Castiglione-Gertsch M, Thürlimann B, Hiltbrunner A, Egli G, Rabaglio M, Maibach R, Marbot E, Studer R, Schärlig-Strausak M, Gelber RD, Price KN, Regan MM, Cole B, Sun Z, Zahrieh D, Gelber S, Giobbie-Hurder A, Blacher L, Celano J, Hinkle R, Isley M, Scolese T, Gusterson B, Viale G, Mallon E, Bernhard J, Hürny Ch, Gusset H, Mathys N, Cliffe B, Rudenstam CM, Wallgren A, Ottosson-Lönn S, Hultborn R, Colldahl-Jädeström G, Cahlin E, Mattsson J, Holmberg SB, Ruusvik O, Niklasson LG, Dahlin S, Karlsson G, Lindberg B, Sundbäck A, BergegArdh S, Groot O, Dahlbäck LO, Salander H, Andersson C, Heideman M, Nissborg A, Wallin A, Claes G, Ramhult T, Svensson JH, Liedberg P, Nilsson A, Havel G, Oestberg G, Persson S, Suurkla M, Matusik J, Veronesi A, Crivellari D, Monfardini S, Galligioni E, Magri MD, Buonadonna A, Massarut S, Rossi C, Candiani E, Carbone A, Volpe R, Roncadin M, Arcicasa M, Coran F, Morassut S, Goldhirsch A, Colleoni M, Martinelli G, Peruzzotti G, Orlando L, Nolè F, Torrisi R, Luini A, Orecchia R, Viale G, Peccatori F, de Braud F, Costa A, Zurrida S, Veronesi P, Sacchini V, Galimberti V, Intra M, Veronesi U, Foladore S, Foghin L, Pamich G, Bianchi C, Marino B, Murgia A, Milan V, Simoncini E, Marini G, Marpicati P, Braga M, Grigolato P, Lucini L, Lindtner J, Erzen D, Cufer T, Cervek J, Cerar O, Zakotnik B, Majdic E, Golouh R, Lamovec J, Jancar J, Vrhovec I, Kramberger M, Cortès-Funes H, Mendiola D, Gravalos C, Colomer, Mendez M, Cruz Vigo F, Miranda P, Sierra A, Martinez-Tello F, Garzon A, Alonso S, Ferrero A, Vargas C, Forbes JF, Lindsay D, Forbes JF, Bishop J, Bray S, Stewart J, Ackland S, Bonaventura A, Jackson D, Foster H, Cox S, Gourlay R, Sillar R, O'Brien P, Hamilton C, Denham J, Brew S, Collins J, Snyder R, Abdi E, Basser R, Burns I, Chipman M, Chirgwin J, Drummond R, Francis P, Green M, Gregory P, Hart S, Henderson M, Kitchen P, McLennan R, Murphy C, Neil S, Pitcher M, Richardson G, Rodger A, Schwarz M, Olver I, Robertson A, Gill P, Carter ML, Malycha P, Yeoh E, Ward G, Leong AS, Lommax-Smith J, Hoosfall D, D'Angelo R, Byrne M, van Hazel G, Dewar J, Buck M, Sterret G, Ingram D, Hastrich D, Joseph D, Cameron F, Tattersall MH, Coates AS, Niesche F, Renwick S, Donovan J, Duval P, Simes RJ, Ng A, Glenn D, North RA, Beith J, O'Connor RG, Rice M, Stevens G, Grassby J, Pendlebury S, McLeod C, Boyer M, Sullivan A, Hobbs J, Kay RG, Harvey VJ, Benjamin CS, Thompson P, Bierre A, Miller M, Hochstein B, Lethaby A, Webber J, Fey MF, Castiglione-Gertsch M, Dreher E, Schneider H, Aebi S, Buser K, Ludin J, Beck G, Haenel A, Lüthi JM, Altermatt HJ, Nandedkar M, Senn HJ, Thürlimann B, Oehlschlegel Ch, Ries G, Töpfer M, Lorenz U, Ehrsam A, Späti B, Vogel E, Cavalli F, Pagani O, Neuenschwander H, Bronz L, Sessa C, Ghielmini M, Rusca T, Rey P, Bernier J, Pedrinis E, Gyr T, Leidi L, Pastorelli G, Goldhirsch A, Caccia G, Herrmann R, Rochlitz CF, Harder JF, Köchli O, Eppenberger U, Torhorst J, Perey L, Leyvraz S, Anani P, Genton C, Gomez F, De Grandi P, Reymond P, Mirimanoff R, Gillet M, Delaloye JF, Alberto P, Bonnefoi H, Schäfer P, Krauer F, Forni M, Aapro M, Egeli R, Megevand R, Jacot-des-Combes E, Schindler A, Borisch B, Diebold S, Egli F, Forrer P, Willi A, Steiner R, Allemann J, Rüedi T, Leutenegger A, Dalla Torre U.

Author information

1
Senology Center of Eastern Switzerland, Kantonsspital, St. Gallen, Switzerland. beat.thuerlimann@kssg.ch

Abstract

INTRODUCTION:

International Breast Cancer Study Group (IBCSG) Trial 11-93 is the largest trial evaluating the role of the addition of chemotherapy to ovarian function suppression/ablation (OFS) and tamoxifen in premenopausal patients with endocrine-responsive early breast cancer.

METHODS:

IBCSG Trial 11-93 is a randomized trial comparing four cycles of adjuvant chemotherapy (AC: doxorubicin or epirubicin, plus cyclophosphamide) added to OFS and 5 years of tamoxifen versus OFS and tamoxifen without chemotherapy in premenopausal patients with node-positive, endocrine-responsive early breast cancer. There were 174 patients randomized from May 1993 to November 1998. The trial was closed before the target accrual was reached due to low accrual rate.

RESULTS:

Patients randomized tended to have lower risk node-positive disease and the median age was 45. After 10 years median follow up, there remains no difference between the two randomized treatment groups for disease-free (hazard ratio=1.02 (0.57-1.83); P=0.94) or overall survival (hazard ratio=0.97 (0.44-2.16); P=0.94).

CONCLUSION:

This trial, although small, offers no evidence that AC chemotherapy provides additional disease control for premenopausal patients with lower-risk node-positive endocrine-responsive breast cancer who receive adequate adjuvant endocrine therapy. A large trial is needed to determine whether chemotherapy adds benefit to endocrine therapy for this population.

PMID:
18259856
PMCID:
PMC2898181
DOI:
10.1007/s10549-008-9912-9
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center