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Cell Death Differ. 2008 Apr;15(4):628-34. doi: 10.1038/cdd.2008.17. Epub 2008 Feb 15.

Biology of hypoxia-inducible factor-2alpha in development and disease.

Author information

1
Department of Cell and Developmental Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Abstract

The transcriptional response to hypoxia is primarily mediated by two hypoxia-inducible factors--HIF-1alpha and HIF-2alpha. While these proteins are highly homologous, increasing evidence suggests they have unique transcriptional targets and differential impact on tumor growth. Furthermore, non-transcriptional effects of the HIF-alpha subunits, including effects on the Notch and c-Myc pathways, contribute to their distinct functions. HIF-2alpha transcriptional targets include genes involved in erythropoiesis, angiogenesis, metastasis, and proliferation. Therefore, HIF-2alpha contributes significantly to both normal physiology as well as tumorigenesis. Here, we summarize the function of HIF-2alpha during development as well as its contribution to pathologic conditions, such as tumors and vascular disease.

PMID:
18259197
PMCID:
PMC2882207
DOI:
10.1038/cdd.2008.17
[Indexed for MEDLINE]
Free PMC Article

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