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Curr Opin Chem Biol. 2008 Feb;12(1):86-92. doi: 10.1016/j.cbpa.2008.01.031. Epub 2008 Mar 4.

Glycan arrays: biological and medical applications.

Author information

1
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Abstract

Carbohydrates and their conjugates are involved in various biological events, including viral and bacterial infection, the immune response, differentiation and development, and the progression of tumor cell metastasis. Glycan arrays are a new technology that has enabled the high-sensitivity and rapid analysis carbohydrate-protein interaction and contribute to significant advances in glycomics. Glycan arrays use a minute amount of materials and can be used for high-throughput profiling and quantitative analysis and provide information for the development of carbohydrate-based vaccines and new drug discovery.

PMID:
18258211
DOI:
10.1016/j.cbpa.2008.01.031
[Indexed for MEDLINE]

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