Format

Send to

Choose Destination
FEBS Lett. 2008 Mar 5;582(5):768-72. doi: 10.1016/j.febslet.2008.01.049. Epub 2008 Feb 5.

Structural features of protein folding nuclei.

Author information

1
Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, Russia. sergey@alpha.protres.ru

Abstract

A crucial event of protein folding is the formation of a folding nucleus. We demonstrate the presence of a considerable coincidence between the location of folding nuclei and the location of so-called "root structural motifs", which have unique overall folds and handedness. In the case of proteins with a single root structural motif, the involvement in the formation of a folding nucleus is in average significantly higher for amino acids residues that are in root structural motifs, compared to residues in other parts of the protein. The tests carried out revealed that the observed difference is statistically reliable. Thus, a structural feature that corresponds to the protein folding nucleus is now found.

PMID:
18258199
DOI:
10.1016/j.febslet.2008.01.049
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center