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FEBS Lett. 2008 Mar 5;582(5):725-8. doi: 10.1016/j.febslet.2008.01.047. Epub 2008 Feb 5.

Activation of NO donors in mitochondria: peroxidase metabolism of (2-hydroxyamino-vinyl)-triphenyl-phosphonium by cytochrome c releases NO and protects cells against apoptosis.

Author information

1
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA. stoyanovskyd@upmc.edu

Erratum in

  • FEBS Lett. 2008 May 14;582(11):1634. Greenberger, Joel S [added].

Abstract

In mitochondrial apoptosis, the formation of cytochrome c-cardiolipin complex ([CL-cyt c]) with peroxidase properties is an early event in the cascade of reactions that leads to cell death. Herein, we report the synthesis of a new prodrug, (2-hydroxyamino-vinyl)-triphenyl-phosphonium (HVTP), which compartmentalizes exclusively into mitochondria, undergoes a [CL-cyt c]-catalyzed bioactivation to nitric oxide (NO), inhibits peroxidase activity, and protects cells from apoptosis.

PMID:
18258194
PMCID:
PMC2275320
DOI:
10.1016/j.febslet.2008.01.047
[Indexed for MEDLINE]
Free PMC Article

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