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J Zhejiang Univ Sci B. 2008 Feb;9(2):85-9. doi: 10.1631/jzus.B0710617.

BRCA1/2 associated hereditary breast cancer.

Author information

1
Cancer Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China. lsteng@zju.edu.cn

Abstract

Breast cancer is one of the leading causes of death in women today. Some of the patients are hereditary, with a large proportion characterized by mutation in BRCA1 and/or BRCA2 genes. In this review, we provide an overview of these two genes, focusing on their relationship with hereditary breast cancers. BRCA1/2 associated hereditary breast cancers have unique features that differ from the general breast cancers, including alterations in cellular molecules, pathological bases, biological behavior, and a different prevention strategy. But the outcome of BRCA1/2 associated hereditary breast cancers still remains controversial; further studies are needed to elucidate the nature of BRCA1/2 associated hereditary breast cancers.

PMID:
18257128
PMCID:
PMC2225488
DOI:
10.1631/jzus.B0710617
[Indexed for MEDLINE]
Free PMC Article

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