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J Clin Hypertens (Greenwich). 2008 Feb;10(2):153-7.

Pseudohyperaldosteronism, liquorice, and hypertension.

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Hypertension Clinic, Division of Nephrology, Kidney Research Centre, University of Ottawa, Ottawa Health Research Institute, University of Ottawa, ON, Canada.


Consumption of large quantities of liquorice can cause hypokalemia and hypertension. These effects are associated with increased cortisol-mediated activation of renal mineralocorticoid receptors and hypoaldosteronism. The authors describe a patient with long-standing hypokalemia and uncontrolled hypertension related to excessive ingestion of liquorice. The case highlights the importance of obtaining a detailed dietary history, especially considering the increasing use of liquorice-containing foods, teas, and herbal products. The authors also discuss secondary causes of hypertension, focusing on pseudohyperaldosteronism.

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