Send to

Choose Destination
See comment in PubMed Commons below
J Neurophysiol. 2008 Apr;99(4):2021-5. doi: 10.1152/jn.01324.2007. Epub 2008 Feb 6.

Long-term enhancement of synchronized oscillations by adrenergic receptor activation in the olfactory bulb.

Author information

Department of Physiology and Biophysics, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA.


The noradrenergic system is widely thought to be important for associative learning in the olfactory system through actions in the first processing structure, the main olfactory bulb (MOB). Here, we used extracellular local field potential (LFP) and patch-clamp recordings in rat MOB slices to examine norepinephrine (NE)-induced long-term changes in circuit properties that might underlie learning. During responses to patterned olfactory nerve stimulation mimicking the breathing cycle, NE induced a long-term increase in gamma frequency (30-70 Hz) synchronized oscillations. The enhancement persisted long after washout of NE (<or=70 min), depended on the combined actions of NE and neuronal stimulation, and seemed to be caused by enhanced excitatory drive on the mitral/granule cell network that underlies rapid gamma oscillations. The last effect, increased excitation, was manifested as an increase in evoked long-lasting depolarizations (LLDs) in mitral cells. From a functional perspective, the observed long-term cellular and network changes could promote associative learning by amplifying odor-specific signals.

[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center