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Nutr Rev. 2008 Jan;66(1):40-6. doi: 10.1111/j.1753-4887.2007.00004.x.

Vitamin D and adipogenesis: new molecular insights.

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Mineral Bioavailability Laboratory at Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.


The focus of the current review is to highlight some new insights into the molecular mechanism by which vitamin D, a potentially nutritionally modulated factor, influences adipogenesis. Recent studies, predominantly using the mouse 3T3-L1 pre-adipocyte cell culture model, have shown that the role of vitamin D in inhibiting adipogenesis is mediated at the molecular level through a vitamin D receptor (VDR)-dependent inhibition of CCAAT enhancer binding protein-alpha (C/EBP alpha) and peroxisome proliferator-activated receptor-gamma (PPAR gamma) expression and a decrease in PPAR gamma transactivating activity in the pre-adipocyte. The latter action may reflect a vitamin D-induced decrease in endogenous PPAR gamma ligand availability and a competition between VDR and PPAR gamma for a limiting amount of retinoid X receptor (RXR), a common heterodimeric binding partner of both nuclear receptors.

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