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Nutr Rev. 2008 Feb;66(2):103-8. doi: 10.1111/j.1753-4887.2008.00015.x.

Proton pump-inhibiting drugs, calcium homeostasis, and bone health.

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  • 1The University of Connecticut, Department of Allied Health Sciences, Storrs, Connecticut 06269-2101, USA.


Proton pump inhibitors (PPIs) are commonly used drugs, several of which are available without a prescription. Two recent studies have demonstrated increased hip fracture rates associated with PPI use. Theoretically, PPIs could impair intestinal calcium absorption resulting in increased rates of bone loss and a greater risk of fragility fracture.

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