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PLoS One. 2008 Feb 6;3(2):e1560. doi: 10.1371/journal.pone.0001560.

The Plasmodium export element revisited.

Author information

1
Johann Wolfgang Goethe-University, Institute of Cell Biology and Neuroscience, Centre for Membrane Proteomics, Frankfurt am Main, Germany. hiss@bioinformatik.uni-frankfurt.de

Abstract

We performed a bioinformatical analysis of protein export elements (PEXEL) in the putative proteome of the malaria parasite Plasmodium falciparum. A protein family-specific conservation of physicochemical residue profiles was found for PEXEL-flanking sequence regions. We demonstrate that the family members can be clustered based on the flanking regions only and display characteristic hydrophobicity patterns. This raises the possibility that the flanking regions may contain additional information for a family-specific role of PEXEL. We further show that signal peptide cleavage results in a positional alignment of PEXEL from both proteins with, and without, a signal peptide.

PMID:
18253504
PMCID:
PMC2216060
DOI:
10.1371/journal.pone.0001560
[Indexed for MEDLINE]
Free PMC Article
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