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Br J Cancer. 2008 Feb 26;98(4):689-92. doi: 10.1038/sj.bjc.6604234. Epub 2008 Feb 5.

Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma.

Author information

1
Medical Oncology, Department of Medicine, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9.

Abstract

Helicobacter pylori (HP) infection appears protective against oesophageal adenocarcinoma (EA) risk. Matrix metalloproteinases (MMPs) are released in the presence of HP infection. In MMP2 wild-type individuals, HP was significantly protective of EA risk (adjusted odds ratio: 0.29; 95% confidence interval=0.1-0.7). Matrix metalloproteinases may modulate the EA-HP relationship.

PMID:
18253117
PMCID:
PMC2259195
DOI:
10.1038/sj.bjc.6604234
[Indexed for MEDLINE]
Free PMC Article

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