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J Clin Endocrinol Metab. 2008 Apr;93(4):1123-8. doi: 10.1210/jc.2007-2449. Epub 2008 Feb 5.

Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor.

Author information

1
National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.

Abstract

CONTEXT:

The insulinoma syndrome is marked by fasting hypoglycemia and inappropriate elevations of insulin. The gastrinoma syndrome is characterized by hypergastrinemia, ulcer disease, and/or diarrhea. Rarely, insulinoma and gastrinoma coexist in the same patient simultaneously.

OBJECTIVE:

Our objective was to determine the cause of a patient's hypoglycemic episodes and peptic ulcer disease.

DESIGN AND SETTING:

This is a clinical case report from the Clinical Research Center of the National Institutes of Health.

PATIENT AND INTERVENTION:

One patient with hypoglycemic episodes and peptic ulcer disease had a surgical resection of neuroendocrine tumor.

RESULTS:

The patient was found to have a single tumor cosecreting both insulin and gastrin. Resection of this single tumor was curative.

CONCLUSIONS:

A single pancreatic neuroendocrine tumor may lead to the expression of both the hyperinsulinemic and hypergastrinemic syndromes.

PMID:
18252785
PMCID:
PMC2291484
DOI:
10.1210/jc.2007-2449
[Indexed for MEDLINE]
Free PMC Article

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