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J Neurooncol. 2008 May;88(1):97-103. doi: 10.1007/s11060-008-9538-0. Epub 2008 Feb 5.

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma in elderly patients.

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  • 1Department of Radiotherapy Oncology, S Andrea Hospital, University La Sapienza, Via di Grottarossa 1035, Rome, Italy. Giuseppe.Minniti@ospedalesantandrea.it

Abstract

OBJECTIVES:

The optimal treatment for elderly patients (age > 70 years) with glioblastoma remains controversial. We conducted a prospective trial in 32 consecutive elderly patients with glioblastoma who underwent surgery followed by radiotherapy (RT) plus concomitant and adjuvant temozolomide.

PATIENTS AND METHODS:

32 patients 70 years of age or older with a newly diagnosed glioblastoma and a Karnofsky performance status (KPS) > or = 70 were treated with RT (daily fractions of 2 Gy for a total of 60 Gy) plus temozolomide at the dose of 75 mg/m(2) per day followed by six cycles of adjuvant temozolomide (150-200 mg/m(2) for 5 days during each 28-day cycle). The primary endpoint was overall survival (OS). Secondary endpoints included progression free survival (PFS) and toxicity.

RESULTS:

The median OS was 10.6 months and the median PFS was 7 months. The 6-month and 12-month survival rates were 91% and 37%, respectively. The 6-month and 12-month PFS rates were 56% and 16%, respectively. In multivariate analysis KPS was the only significant independent predictive factor of survival (P = 0.01). Adverse effects were mainly represented by neurotoxicity (40%), which resolved in most cases with the use of steroids, and Grade 3-4 hematologic toxicity in 28% of patients. Chemotherapy was stopped in 2 patients, delayed in 9 patients and reduced in 4 patients.

CONCLUSIONS:

Standard RT plus concomitant and adjuvant temozolomide is a feasible treatment for elderly patients with newly diagnosed glioblastoma who present with good prognostic factors.

PMID:
18250965
DOI:
10.1007/s11060-008-9538-0
[PubMed - indexed for MEDLINE]
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