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Nat Prod Rep. 2008 Feb;25(1):25-34. doi: 10.1039/b707678a. Epub 2007 Sep 4.

Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products.

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1
Environmental Research Institute, University College Cork, Lee Road, Cork, Ireland. jonathan.kennedy@ucc.ie

Abstract

The combination of biological and chemical approaches for the generation of new and diverse natural products holds much promise. While mutasynthesis based approaches are still very relevant, more recent approaches have utilised genetic and metabolic engineering to generate key intermediates for chemical syntheses. This new semi-synthetic approach exploits the ability of biological systems to efficiently generate complex chiral molecules and of synthetic chemistry to elaborate these into new, or difficult to source, molecules.

PMID:
18250896
DOI:
10.1039/b707678a
[Indexed for MEDLINE]
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